During 2021, it was not just COVID-19-related news articles that were most read on Chronicle.lu; however, two such articles did make the list.

Other top-10 articles included news in the following sectors/topics: ecology, environment/transport, cinema, indexes and innovation.

The top-10 most-read articles on Chronicle.lu in 2021 were as follows (in chronological order):

- European Commission Concludes Preliminary Talks to Secure Valneva Vaccine, Orders 300m More Pfizer Doses (12 Jan 2021) 
- EC Proposes Update to Coordinated Approach on COVID-19 Free Movement Restrictions (25 Jan 2021)  
- Paul Wurth, Encevo become Industrial Investors in DataThings (1 Feb 2021) 
- Encevo Group Joins Forces with LIST, SnT to Accelerate Sustainable Energy Transition (12 Feb 2021)  
- 5 Student Teams Rewarded at My First Enterprise Competition (10 May 2021)  
- Activities Planned in Nommern for International Bat Night (12 Jul 2021)  
- British & Irish Film Festival Luxembourg Returns with Hybrid 12th Edition (3 Sep 2021)  
- Car Cost Index 2021 Shows Electric Vehicles Are Now Competitive re TCO (2 Nov 2021)  
- Luxembourg Climbs to 8th Place in Digital Economy and Society Index  (15 Nov 2021) 
Luxembourg Climbs 3 Places in Climate Change Performance Index  (15 Nov 2021)